鼻内给药 comes up often in conversation and rarely with the context attached. Here we lay out the basics in order, then work through the practical considerations.
Last reviewed on 2025-09-28. Where a claim depends on a specific study, the study is described rather than over-claimed.
当时的短肽研究普遍关注能否穿越血脑屏障、在低剂量下产生中枢效应，Semax 属于这一路线。鼻内给药是其主要使用方式，俄语文献报道的适应症涵盖缺血性卒中、短暂性脑缺血发作、认知功能减退以及视神经病变。这些研究大多发表在当地期刊上，样本规模与终点设置同西方试验惯例存在差异，国际同行对其临床证据的强度看法不一。
各国监管态度分化明显。俄罗斯按处方药管理，部分东欧国家留有使用记录；欧盟与美国未批准其作为药物上市，市面流通品通常标注为研究用化学品。身份差异意味着标示含量、纯度与无菌性缺少统一核查。体育领域还牵涉反兴奋剂名录，跨境携带则受目的地药品法规约束。
Semax 是人工设计的七肽，序列为 Met-Glu-His-Phe-Pro-Gly-Pro，骨架取自促肾上腺皮质激素片段 ACTH(4-10)。它于二十世纪八十年代在苏联的分子遗传学研究机构内合成。设计目标是保留该片段与注意力和记忆相关的活性，同时剔除促皮质激素释放等内分泌作用。此后俄罗斯将其登记为药品并进入临床使用。
Proposed mechanisms center on neurotrophic signaling rather than on classical melanocortin receptor activation. Rodent experiments have reported shifts in the expression of brain-derived neurotrophic factor and nerve growth factor after administration, together with changes in the associated receptor systems. Several authors argue that the peptide acts largely through its degradation products and their interaction with peptidergic pathways, but this remains a hypothesis rather than a settled finding. No single molecular target has been identified in a way that the field broadly accepts.
Published research covers ischemic stroke, traumatic brain injury, cognitive impairment, optic nerve conditions and attention-related measures. Much of the human evidence comes from small trials conducted in one country, which limits how far the results generalize. Animal models supply the larger share of the data, and effects seen in rodents do not transfer automatically to people. Reviews have noted that methodological reporting is often incomplete, making it difficult to pool results or compare treatment schedules across studies.
Pharmacokinetic accounts emphasize rapid breakdown. After intravenous dosing the intact peptide disappears from blood within minutes, and nasal delivery produces low but measurable concentrations. Metabolites rather than the parent molecule may account for part of the observed activity, although the relative contribution is unresolved. Dosing in the literature varies widely and no optimal schedule has been agreed. These gaps are regularly cited as a reason the findings have not produced broad clinical adoption beyond the original research setting.
| Property | Value | Notes |
|---|---|---|
| 结构类别 | 线性合成七肽 | 无环化结构，不含二硫键 |
| 氨基酸序列 | Met-Glu-His-Phe-Pro-Gly-Pro | N 端为甲硫氨酸 |
| 分子量 | 约 814 Da | 游离碱形式的计算值 |
| 外观 | 白色至类白色粉末 | 具吸湿性 |
| 溶解性 | 易溶于水 | 亦可溶于甲醇等极性溶剂 |
Semax is a synthetic heptapeptide with the sequence Met-Glu-His-Phe-Pro-Gly-Pro. It corresponds to the ACTH(4-7) fragment extended at the C-terminus by a Pro-Gly-Pro tripeptide, an addition intended to slow enzymatic breakdown. The molecular formula is C37H51N9O10S and the molecular mass is approximately 814 daltons. In the literature it is often described as an ACTH(4-10) analog, although that label reflects a naming convention as much as a precise structural relationship. The compound was developed in Russia and remains most closely associated with that research tradition.
Laboratory descriptions of the material are consistent across suppliers. It appears as a white to off-white lyophilized powder that dissolves readily in water and in polar organic solvents such as dimethyl sulfoxide. Aqueous solutions are clear and colorless at low concentrations. Because the peptide contains methionine, oxidation at the sulfur atom is a recognized degradation pathway, and handling notes usually call for protected, desiccated storage. Reported purity for research-grade lots is generally above 95 percent as measured by reversed-phase high-performance liquid chromatography.
The compound is registered in Russia as a pharmaceutical product, most commonly formulated as a nasal solution, and has been used in that setting since the 1990s. Outside that jurisdiction it is generally handled as a research chemical rather than an approved medicine. Regulatory status therefore differs sharply between countries, and material sold internationally may not correspond to the Russian pharmaceutical formulation. Documentation with commercial samples is typically limited to a certificate of analysis covering purity and identity, not clinical status or local legal classification.
Identity and purity of semax are established with reversed-phase high-performance liquid chromatography coupled to ultraviolet detection, usually at 214 nanometres. Mass spectrometry, most often electrospray ionisation in positive mode, confirms the molecular mass and reveals truncated sequences. Amino acid analysis and peptide mapping after enzymatic digestion provide additional structural confirmation. Laboratories typically report purity as the percentage area of the main peak, a figure that does not capture isomeric or oxidised variants unless the method resolves them.
The peptide is prone to several degradation pathways. Oxidation of the methionine residue produces a sulfoxide that elutes close to the parent peak in many chromatographic systems. Hydrolysis of peptide bonds and deamidation of susceptible residues in related sequences also reduce purity over time. Lyophilised material kept dry at minus twenty degrees Celsius and shielded from light is the most stable form commonly described in laboratory practice.
Semax is a synthetic heptapeptide with the sequence Met-Glu-His-Phe-Pro-Gly-Pro. It was derived from the ACTH(4-10) fragment, a short segment of adrenocorticotropic hormone that lacks the hormonal activity associated with the full-length peptide. Researchers at the Institute of Molecular Genetics in Moscow developed the compound during the 1980s. It has been registered as a pharmaceutical product in Russia and several neighbouring countries, where it is supplied as a nasal solution, and it is also sold internationally as a research chemical.
The proposed mechanism centres on neurotrophic signalling rather than direct receptor activation. Semax is reported to increase expression of brain-derived neurotrophic factor and nerve growth factor in several brain regions, and to shift the balance between excitatory and inhibitory neurotransmitter systems. Interaction with melanocortin receptors has been suggested because of the parent ACTH fragment. Many of these findings come from rodent studies, and the extent to which they translate to human physiology remains an open question.
Bolsonaro was welcomed by Hungarian ambassador to Brazil Miklós Halmai who reportedly sent the embassy's local employees a message to work from home during those dates. Following the report, the Supreme Court gave Bolsonaro a 48-hour deadline to explain his stay in the embassy, and the Federal Police announced it was opening an investigation into the incident; which could have been viewed as an attempt to escape justice via diplomatic asylum, since embassies are typically considered inviolable and host countries cannot enforce their law inside them without permission. Media commentators and people on social media speculated this hypothesis was likely to be true citing Bolsonaro and Hungarian prime minister Viktor Orbán are both right-wing populist politicians who share a personal friendship, and Hungary's previous granting of asylum to the sanctioned former Macedonian prime minister Nikola Gruevski. Additionally, the Ministry of Foreign Affairs summoned Halmai to give explanations about Bolsonaro's two-night stay in the embassy. On 19 March 2024 the Federal Police formally accused Bolsonaro of fraud on his COVID-19 vaccine records. In November 2024 he and 36 others were formally charged with plotting a coup d'état, violent abolition of the democratic rule of law, and criminal organisation. In February 2025 Bolsonaro and 33 others were formally charged with plotting to assassinate Lula da Silva and Supreme Court Justice Alexandre de Moraes. On 26 March the Supreme Federal Court ordered Bolsonaro and seven of his associates to stand trial over the charges.
Emission of neutrons during the fission of uranium is important not only for maintaining the nuclear chain reaction, but also for the synthesis of the heavier actinides. Uranium-239 converts via β-decay into plutonium-239, which, like uranium-235, is capable of spontaneous fission. The world's first nuclear reactors were built not for energy, but for producing plutonium-239 for nuclear weapons. About half of produced thorium is used as the light-emitting material of gas mantles. Thorium is also added into multicomponent alloys of magnesium and zinc. Mg-Th alloys are light and strong, but also have high melting point and ductility and thus are widely used in the aviation industry and in the production of missiles. Thorium also has good electron emission properties, with long lifetime and low potential barrier for the emission. The relative content of thorium and uranium isotopes is widely used to estimate the age of various objects, including stars (see radiometric dating). The major application of plutonium has been in nuclear weapons, where the isotope plutonium-239 was a key component due to its ease of fission and availability. Plutonium-based designs allow reducing the critical mass to about a third of that for uranium-235. The "Fat Man"-type plutonium bombs produced during the Manhattan Project used explosive compression of plutonium to obtain significantly higher densities than normal, combined with a central neutron source to begin the reaction and increase efficiency. Thus only 6.2 kg of plutonium was needed for an explosive yield equivalent to 20 kilotons of TNT.
=== A10BK Sodium-glucose co-transporter 2 (SGLT2) inhibitors === A10BK01 Dapagliflozin A10BK02 Canagliflozin A10BK03 Empagliflozin A10BK04 Ertugliflozin A10BK05 Ipragliflozin A10BK06 Sotagliflozin A10BK07 Luseogliflozin A10BK08 Bexagliflozin A10BK09 Enavogliflozin QA10BK90 Velagliflozin
Sources: en.wikipedia.org
Elements are composed either of one nuclide (mononuclidic elements), or of more than one naturally occurring isotopes. The unstable (radioactive) isotopes are either primordial or postprimordial. Primordial isotopes were a product of stellar nucleosynthesis or another type of nucleosynthesis such as cosmic ray spallation, and have persisted down to the present because their rate of decay is very slow (e.g. uranium-238 and potassium-40). Post-primordial isotopes were created by cosmic ray bombardment as cosmogenic nuclides (e.g., tritium, carbon-14), or by the decay of a radioactive primordial isotope to a radioactive radiogenic nuclide daughter (e.g. uranium to radium). A few isotopes are naturally synthesized as nucleogenic nuclides, by some other natural nuclear reaction, such as when neutrons from natural nuclear fission are absorbed by another atom. As discussed above, only 80 elements have any stable isotopes, and 26 of these have only one stable isotope. Thus, about two-thirds of stable elements occur naturally on Earth in multiple stable isotopes, with the largest number of stable isotopes for an element being ten, for tin (50Sn). There are about 94 elements found naturally on Earth (up to plutonium inclusive), though some are detected only in very tiny amounts, such as plutonium-244. Scientists estimate that the elements that occur naturally on Earth (some only as radioisotopes) occur as 339 isotopes (nuclides) in total. Only 251 of these naturally occurring nuclides are stable, in the sense of never having been observed to decay as of the present time.
=== 21st century === In 2001, UPS acquired Mail Boxes Etc., Inc., a franchised network of packing and shipping retail centers across the United States and Canada. In 2003, the company rebranded the Mail Boxes, Etc. network as The UPS Store. In 2004, UPS entered the heavy freight business with the purchase of Menlo Worldwide Forwarding, a former subsidiary of Menlo Worldwide; UPS rebranded it as UPS Supply Chain Solutions. The purchase price was US$150 million and the assumption of US$110 million in long-term debt. On August 5, 2005, UPS announced that it had completed its acquisition of less-than-truckload (LTL) trucking company Overnite Transportation for US$1.25 billion. This was approved by the FTC and Overnite shareholders on August 4, 2005. On April 28, 2006, Overnite officially became UPS Freight. In 2005, UPS offered non-stop delivery service between Guangzhou and the United States. On October 3, 2005, UPS completed the purchase of Lynx Express, one of the largest independent parcel carriers in the United Kingdom, for £55.5 million (US$97.1 million) after receiving approval for the transaction from the European Commission. The first joint package car center operation in Dartford, Kent, was opened in 2006. On August 28, 2007, United Parcel Service celebrated its 100th anniversary. All Nippon Airways, a Star Alliance member, and UPS formed a cargo alliance and codeshare agreement to transport member cargo in 2008, similarly to an airline alliance.
Apart from several bog bodies, Denmark has also yielded several other mummies, such as the three Borum Eshøj mummies, the Skrydstrup Woman and the Egtved Girl, who were all found inside burial mounds, or tumuli. In 1875, the Borum Eshøj grave mound was uncovered, which had been built around three coffins, which belonged to a middle aged man and woman as well as a man in his early twenties. Through examination, the woman was discovered to be around 50–60 years old. She was found with several artifacts made of bronze, consisting of buttons, a belt plate, and rings, showing she was of higher class. All of the hair had been removed from the skull later when farmers had dug through the casket. Her original hairstyle is unknown. The two men wore kilts, and the younger man wore a sheath which contained a bronze dagger. All three mummies were dated to 1351–1345 BC. The Skrydstrup Woman was unearthed from a tumulus in Southern Jutland, in 1935. Carbon-14 dating showed that she had died around 1300 BC; examination also revealed that she was around 18–19 years old at the time of death, and that she had been buried in the summertime. Her hair had been drawn up in an elaborate hairstyle, which was then covered by a horse hair hairnet made by the sprang technique. She was wearing a blouse and a necklace as well as two golden earrings, showing she was of higher class. The Egtved Girl, dated to 1370 BC, was also found inside a sealed coffin within a tumulus, in 1921. She was wearing a bodice and a skirt, including a belt and bronze bracelets.
Sources: en.wikipedia.org
=== Disorders of mineral metabolism === 275 Disorders of mineral metabolism 275.0 Disorders of iron metabolism Aceruloplasminemia Hemochromatosis 275.1 Disorders of copper metabolism Wilson's disease 275.2 Disorders of magnesium metabolism Hypermagnesemia Hypomagnesemia 275.3 Disorders of phosphorus metabolism Familial hypophosphatemia Hypophosphatasia 275.4 Disorders of calcium metabolism 275.41 Hypocalcemia 275.42 Hypercalcemia 275.49 Pseudohypoparathyroidism
Venous thrombosis is the formation of a thrombus (blood clot) in a vein. This most commonly affects a deep vein known as deep vein thrombosis (DVT), but can also affect a superficial vein known as superficial vein thrombosis (SVT).
Nelumbo nucifera contains some thermal-stable proteins that might be useful in protein bioengineering processes. The proteins are characterized by seed longevity used for cell protection and repair under stress. There are also several indications that compounds of N. nucifera are used in drug fabrication in human health research for multiple purposes. Lotus leaves possess hydrophobic characteristics, attributed to a waxy coat that prevents water from adhering to the surface. This attribute has influenced the conception of the "lotus effect" in biomimicry and engineering, guiding the design of materials that resist water and remain self-cleaning. Researchers at the National University of Singapore have utilized the water-repelling structure as inspiration for developing eAir, an aero-elastic sensor capable of detecting subtle pressure changes or other environmental stimuli.
Sources: en.wikipedia.org
不存在。它是依据 ACTH 的一段序列人工设计的分子，天然蛋白质中找不到与之完全相同的七肽。名称属于研究代号，而非天然物质名。
Semax 对应 ACTH 第 4 至第 10 位的片段，并在两端做了替换与延长，使其不再具备促肾上腺皮质激素的典型内分泌活性。这一改动同时改变了它在体内的稳定性与分布特征。
俄罗斯将其列为处方药物，需要医生开具处方。多数其他国家把它当作研究化合物，不能作为药品销售或宣称疗效。具体合法性取决于当地法规。
The main proposal is modulation of neurotrophic factors such as brain-derived neurotrophic factor, supported largely by animal experiments. Receptor-level targets have not been firmly established. Most reviews describe the mechanism as only partially characterized.